ITRACONAZOLE NANOSUSPENSIONS VIA DUAL CENTRIFUGATION MEDIA MILLING: IMPACT OF FORMULATION AND PROCESS PARAMETERS ON PARTICLE SIZE AND SOLID-STATE CONVERSION AS WELL AS STORAGE STABILITY

Nanocrystal suspensions proved to be a potent enabling principle for biopharmaceutics classification system class II drugs with dissolution limited bioavailability.In the example of itraconazole (ITZ) as a model drug combined with electrosteric stabilization using hydroxypropyl cellulose (HPC-SL), sodium dodecyl sulfate (SDS) and polysorbate 80 (PS

Objective Saturated loess slump may lead to underground cavity.When the underground tunnel passes through the fortified fissures section of the self-weighty saturated slump loess site, the encountered underground cavity may likely bring about mud in-rush disaster.Effective treatment measures need Mirrored Dresser with Fireplace be taken to control

Meat cultivation via cellular agriculture holds great promise as a method for future food production.In theory, it is an ideal way of meat production, humane to the animals and sustainable for the environment, while keeping the same taste and nutritional values as traditional meat and having additional benefits such as controlled fat content and ab

Infants remain at high risk for severe coronavirus disease 2019 (COVID-19).Human milk contains high levels of protective SARS CoV-2 specific antibodies post-infection and primary vaccine series, but levels decline over time.We hypothesized that the COVID-19 booster vaccine augment antibody production and the protection afforded to human milk-fed in